GSS EU Science Funding Gateway

The risks from exposure to biological toxins in the hot zone are largely unknown. In order to recommend appropriate protective equipment for first responders and to guide the use of effective decontamination measures, the risks from exposure need to be assessed, taking into account sex susceptibility to toxins exposure.

Following an attack, exposed personnel, equipment and facilities needs to be decontaminated and declared safe as quickly as possible, in order limit the effects on society. Most decontamination procedures are developed for chemical or biological (i.e. organisms and viruses) agents, but based on their characteristics, biological toxins are at the interface of classical biological and chemical agents. Therefore, the efficiency of existing decontamination procedures should be evaluated for the decontamination of biological toxins.

Previous initiatives have initiated standardisation efforts for lab-based detection and identification of biological toxins. Analytical tools and reference materials are available and comprehensive training and proficiency-testing programs were organised, however, the need for further technical and operational improvement was demonstrated. Building on existing initiatives and networks, a consolidated platform should be established providing analytical tools (including Certified Reference Materials), training and intercomparisons among laboratories. Following the initial detection of the used biological toxin, a more detailed analysis is needed in order to link the agent to confiscated materials. In support of criminal investigations, new procedures and guidelines for comprehensive forensic analysis of biological toxins are needed. The developed methods and procedures should be shared among specialised and forensic laboratories. This action is also expected to engage with the European Health Emergency Preparedness and Response Authority (HERA).

In this context it is important to remind that standardisation should support operations and policymaking to supplement it but should by no means substitute it. While standardisation of technology may be more straightforward, the right balance does especially have to be sought for processes. The action should ensure close synergies with standardisation activities on European (e.g. CEN/TC 391) and international level (e.g. ISO/TC 292).