GSS EU Science Funding Gateway

There is a need to better understand which risk factors and determinants affect the development and progression of cancer and how.

Proposals should address all of the following:

• Develop a systematic understanding of cellular processes with a focus on the transition from a healthy state to cancer initiation and progression, at the individual or population level.
• Demonstrate access to and use of multiple comprehensive databases in and well beyond health research and health domains, such as lifestyle, omics, clinical, indoor and outdoor exposure, environmental, urban areas and sprawl, climate, agricultural crop and land use, geo-positioning, and remote sensing. Proposals should build on longitudinal cohorts, case-control studies, biobanks, registries and many other initiatives, and use state-of-the art digital tools for data analyses and modelling, wherever possible.
• Analyse and integrate existing knowledge and high-quality data from biomedical and clinical studies, using advanced technologies such as computer modelling, AI and machine learning with the objective to identify factors and determinants triggering the transition from the healthy state to the initiation and progression of poorly understood cancers and cancer subtypes, including in children and adolescents.
• The influence of age, including in utero and early-life factors and determinants; environmental factors; genetic and epigenetic risk; socio-economic status; behavioural, including lifestyle risk factors; as well as social, cultural, sex and gender aspects including inequalities, should be taken into account across all aspects mentioned above.